Frontline

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Frontline KillS 98-100% Of Adult Fleas On Your Dog Within 24 Hours, AND Contains A Special Ingredient That Kills Flea Eggs And Larvae, Too

Merial Introduces Next Generation In Flea And Tick Prevention

November 9

FRONTLINE Plus for Dogs and FRONTLINE Plus for Cats Combine Proven Effectiveness of Fipronil with IGR

Merial, the world's leading animal health company, announced today that it has recently received approvals from the U.S. Environmental Protection Agency (EPA) to market FRONTLINE Plus (fipronil/(S)-methoprene) for Dogs and FRONTLINE Plus for Cats in the United States. These new products combine an adulticide and insect growth regulator for complete flea control and broad-spectrum tick protection for dogs and cats, respectively.

FRONTLINE Plus combines fipronil, the active ingredient in other FRONTLINE brand products, and (S)-methoprene, an insect growth regulator (IGR), to provide the most effective spot-on flea and tick protection available for dogs and cats, based on registered label claims.

"FRONTLINE is the proven leader in flea and tick control," said Dr. William Ryan, senior director, U.S. veterinary professional services, Merial. "With the development of FRONTLINE Plus, Merial has continued its commitment to develop innovative products to meet the growing and changing needs of pet owners and veterinarians across the country. These revolutionary products for dogs and cats offer complete protection against all flea life stages in one product application - FRONTLINE Plus."

The adulticide, fipronil, kills adult fleas and ticks, while the IGR, (S)-methoprene, kills developing flea eggs and larvae. FRONTLINE Plus is the only topical treatment of its kind that kills all stages of fleas on dogs for up to three months and for up to six weeks on cats, as well as the ticks that transmit serious diseases, including those that may carry Lyme disease. Unlike any other product on the market, FRONTLINE Plus is satisfaction-guaranteed to treat and control the four major kinds of ticks with only one dose.

"For 20 years, (S)-methoprene has proven to be a highly effective IGR, with an excellent safety profile, when used as directed," Ryan said. "Its excellent translocation properties and persistence of activity make it the preferred partner for fipronil."

Veterinarians have increasingly become aware of the importance of helping pet owners protect their pets against flea infestations. Now, with the introduction of FRONTLINE Plus, veterinarians have the ability to proactively control adult and developing fleas from attacking the pet, while also providing the added assurance of protection against ticks.

"We have recognized a remarkable increase in tick-borne diseases in recent years," said Dr. Edward Breitschwerdt, North Carolina State University, College of Veterinary Medicine, Raleigh, N.C. "It is more important than ever that pets -- both dogs and cats -- are protected. Products like FRONTLINE Plus can provide the best protection available for both dogs and cats against the major types of ticks."

Like other FRONTLINE brand products, FRONTLINE Plus is a spot-on flea and tick preventive in a single pipette that is to be applied in a single spot directly to the animal's skin between the shoulder blades.

FRONTLINE Plus offers the same product guarantees pet owners and veterinarians have come to expect -- fast-acting, long-lasting, waterproof and satisfaction-guaranteed. FRONTLINE Plus products can be used on cats and kittens 8 weeks of age or older, and on dogs and puppies 8 weeks of age and older, and over 11 pounds. Merial intends to introduce FRONTLINE Plus into other countries around the world as soon as possible, subject to local regulatory approvals.

Frontline Provides Convenient And Effective Flea And Tick Control For Dogs And Puppies. Frontline Brand Products Are The #1 Choice Of Veterinarians!

• Fast-acting.
• Long-lasting.
• Waterproof Even After Frequent Bathing.
• Prevents Re-infestations.
• Convenient To Use.
• Controls Fleas Which May Cause Flea Allergy Dermatitis.
• Kills All Stages Of 4 Major Ticks, Including Those That May Carry Lyme Disease.
• Use On Puppies 8 Weeks And Older.
• 6 Topical Monthy Treatments.

Frontline FAQ

What is Frontline used for?
Frontline provides convenient and effective flea and tick control for dogs and puppies. It is effective against all stages of the brown dog tick, the American dog tick, lone star tick and deer ticks (the major carrier of Lyme disease).

Availability
Frontline is a non-prescription (OTC) product.

Directions
To kill fleas and all stages of brown dog ticks, American dog ticks, lone star ticks , and deer ticks, apply to dogs and puppies (10 weeks or older) as follows: Hold applicator upright and snap applicator tip away from face and body. Place applicator tip through animals hair to the skin level between the shoulder blades. Squeeze applicator, applying entire contents in a single spot to the animal's skin. Avoid superficial application to the animal's hair. APPLY ONCE A MONTH USING ONE APPLICATOR PER MONTH.

What are the side effects
Pets may experience some temporary irritation at the site of the Frontline product application. If signs persist or become more severe within a few days of application, consult a veterinarian immediately.

What special precautions are there
Frontline is for external use on dogs and puppies 10 weeks or older. Consult a veterinarian before using on medicated animals, animals using this product with other pesticides, and debilitated, aged, pregnant or nursing animals. This product is flammable. Keep away from heat and open flame. This product is harmful to humans if swallowed. Call a physician or poison control center. Drink 1 or 2 glasses of water and induce vomiting unless patient is unconscious. This product can cause eye injury. Flush eyes with plenty of water. Call a physician if irritation persists. Avoid contact with skin, eyesor clothing. Wash thoroughly with soap and water after handling.

In the event of overdose
Contact your veterinarian or veterinary emergency room.

How should I store Frontline?
Store this product at room temperature. Store in the original container only. To dispose wrap original container in several layers of newspaper and discard in trash. Keep out of the reach of children and pets.